The goal of this study was to investigate the relationship between scientific globalization of higher education with students’ academic achievements of Semnan University. Present study is a practical research on the basis of purpose and is a type of descriptive-correlative researches on the basis of data collection method. Statistical population includes all the undergraduates and masters of Semnan University (13000 people) in the academic year 1396-97. Participants were 230 undergraduates and masters of Semnan University (162 undergraduates and 68 masters) who were selected using stratified random sampling method. All the participants completed the questionnaires of scientific globalization of higher education and academic achievements. The data was analyzed by one-sample t-test, correlation coefficient, structural equation model and SPSS and LISREL software. The results indicated that the mean of the importance of the dimensions of scientific globalization of higher education has been evaluated at the desirable level and the mean of students’ academic achievements has been evaluated at a relatively desirable level. There is a significant relationship between students’ academic achievement with international scientific collaborations, global scientific community, increase the speed of scientific development, formation of universal thinking, and social development of academics. Scientific globalization of higher education with regression coefficient of 0.33 has a positive and significant effect on students’ academic achievement. According to findings of the study, in order to enhance the students’ academic achievement in the direction of scientific globalization of higher education, first universal thinking must be shaped in higher education and then, a global scientific community must be formed, the speed of scientific development should be also increased and finally international scientific collaboration with higher education should be provided.