The main purpose of this research is to identify and investigate the organizational factors for implementing open innovation in Iran universities. This study was a qualitative-quantitative research. The field of research in the qualitative section was all open innovation articles and books in the period from 2007 to 2018 and open innovation components were extracted by thematic analysis in an inductive manner. In this research, the "Thematic Network" was used. The validity of the research was approved by the referee by the audit method. To calculate reliability, coding was done by studying row to row of selected resources manually by two individuals individually. After coding, the results of these two coding were compared by the Holsti method. The result of thematic analysis was the extraction of 20 basic themes from different sections of the articles. From these basic themes, 3 organizing themes and finally global theme of “organizational factors” were extracted. Then the proposed innovation model was designed and a questionnaire was prepared for fitting this model. The proposed model has three factors related to the organizational preparation, human resource preparation, and setting up for idea creation, which offered three dimensions for the university to exploit the open innovation. The statistical population in the quantitative part of the research was the managers of the centers of growth and innovation of various universities, including State universities, Islamic azad universities, Payam Noor universities, Scientific and Applied Sciences universities, and Medical universities licensed by the Ministry of Science and also faculty member of entrepreneurship management. To evaluate the content validity of the questionnaire, the Lawshe method was used. In order to study the structural validity of the test, the analysis of the questions was done by confirmatory factor analysis method. All calculated factor loads were greater than 0.6 indicating their favorable condition. Also, all calculated pi values were less than 0.05 which indicated a significant relationship between each factor and the main factor higher than its own. The reliability of the final test was also examined by Cronbach's alpha coefficient. All calculated Cronbach's alpha coefficients were greater than 0.7 which showed reliability acceptable. the results of the validity and reliability testing of the quantitative part confirmed the proposed model.